Antipsychotic drugs and venous thromboembolism

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Fatal venous thromboembolism associated with antipsychotic therapy.

OBJECTIVE To describe the occurrence of pulmonary embolism (PE) as a rare adverse effect of clozapine that is treatable, but sometimes fatal, and survey the literature on the subject in the hope of increasing awareness of the potential danger that may result from drug interactions. CASE SUMMARY A 47-year-old woman treated with clozapine and paroxetine was admitted to the hospital with dyspnea...

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Antipsychotic drugs and risk of venous thromboembolism: nested case-control study.

OBJECTIVE To determine whether antipsychotic drugs are associated with an increased risk of venous thromboembolism, and to examine risks by type of antipsychotic, potency, and dose. DESIGN Population based nested case-control study. SETTING The UK QResearch primary care database. PARTICIPANTS Patients (cases) with a first ever record of venous thromboembolism between 1 January 1996 and 1 ...

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Venous Thromboembolism Following Travel

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[Venous thromboembolism as an adverse effect of antipsychotic treatment].

Many studies, suggest an association between the use of antipsychotics (APs) and occurrence of venous thromboembolism (VTE). Thromboembolism is often related to a significant r'iisk of disability or death. Despite many years of investigating the interrelationsbetween use of APs and VTE, they have not been specified yet. This paper aims to summarize reports on the VTE risk factors in patients us...

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Risk of venous thromboembolism due to antipsychotic drug therapy.

An increasing number of reports suggest a link between venous thromboembolism (VTE) and the use of antipsychotics. To better understand this association the available body of evidence has been critically scrutinised. Relevant articles were identified in the databases Scopus and PubMed. Several observational studies using different methodologies show an increased risk of VTE in psychiatric patie...

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ژورنال

عنوان ژورنال: The Lancet

سال: 2000

ISSN: 0140-6736

DOI: 10.1016/s0140-6736(05)74502-5